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Intrinsic resistance is often decisive for treatment failure; almost half of patients present with baseline resistance, rendering classical therapies ineffective.
Antitumor therapy failure is due to both intrinsic and acquired resistance; intrinsic resistance is often decisive for treatment response.
Here, we demonstrate that pyrosequencing is an accurate, reliable, and time-saving method to detect rare BRAF mutations, which is decisive for treatment with BRAF inhibitors and thus possibly prognosis.
However, our measurement schedule was based on the presumption that the biochemical changes appearing during the first phase of treatment are decisive for treatment result; furthermore the risk of drop-outs increases with the length of the study.
The correlation between the duration of the intertreatment interval and the outcome of the second treatment course was not significant, indicating that it might be not decisive for treatment response if repeated treatments are applied within few months after the first treatment attempt or after years.
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These observations strongly suggest that the valproic acid serum level is not decisive for the treatment response; a more likely explanation is that the responsiveness depends on biological characteristics of the patients.
Success rate is hardly affected because attaining or passing the TDC-level of −0.379 is decisive for considering treatment as being potentially successful rather than the TDC-value itself.
Early diagnosis of cancer is decisive for its successful treatment.
We chose 8-9 months after the standard adjuvant chemotherapy as time point for the DTC-analysis decisive for secondary adjuvant treatment.
If the initial positive Contrast-value is decisive for a post-treatment outcome of a non-successful treatment, a subsequent visit for improvement is lacking because a further follow-up was ended as soon as a patient's treatment was considered as being unsuccessful at one of the three occasions of post-treatment evaluation.
The information on EGFR TKI-associated inD in this study is thought to be decisive; it provides valuable information for treatment considerations and monitoring in Japanese patients with EGFR mutant or wild-type lung cancer.
More suggestions(15)
determinant for treatment
decisive for speech
decisive for independence
decisive for selectivity
decisive for cell
decisive for action
decisive for definition
decisive for fingerprinting
decisive for outcome
decisive for inflation
decisive for tumor
decisive for plaque
decisive for host
decisive for staging
decisive for x
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