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As to the recessiveness of R1135C, we hypothesize that epigenetic factors or the differential effects of the two mutations on activation and recovery of the central pore current may be decisive for development of symptoms and the resulting mode of inheritance.
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This insight is decisive to create a basis for development of new causal therapy modalities.
Frege's step ahead was decisive for the development of logic and foundational study.
While the work of a municipal administration is indeed dominated by 'intellectual and analytical tasks', it is still decisive for the development of a municipality as a whole (with all its social and physical entities) and (hopefully) works for the good of all its citizens.
Thus, a clear understanding of the distinct mechanisms occurring at neuromuscular synapses is decisive for the development and improvement of therapeutic strategies, particularly with nerve agent poisoning, where clinical studies are prevented by ethical considerations.
The measurement of the phototoxic effect, of the pharmacodynamics, and the threshold of response on real physiological systems is a decisive factor for the development of future protocols for PDT and is essential in the early phase of development of new PSs.
Generally, age at infection, dose and frequency of inoculation, and duration of the experiment are decisive for disease development [ 4, 5].
The learning model(s) used in IE curricula are decisive for the intended development of competences in IE disciplines and methods.
Augustine, of decisive importance for the development of the Trinitarian doctrine in Western theology and metaphysics, coupled the doctrine of the Trinity with anthropology.
One way or another, 2015 will be a decisive year for the development of Canada's oil and gas industry.
The lack of GAGE expression in a subset of cancer cells within GAGE-positive tumours has decisive implications for the development of GAGE-targeted cancer therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com