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In this way, the interplay between the different STATs allows the cell to sense complexities in the cytokine environment and the resultant cell phenotype could lie somewhere along a continuum rather than representing a decisive differentiation decision.
Many important and decisive differentiation factors have been discovered, and simple protocols for ESC differentiation into motor neurons are available.
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Later on, when the cells develop tension through the cytoskeleton on these attachment sites, the strength of the integrin adhesion protein-matrix protein interaction might probably prove decisive in differentiation state of the cell.
Christian eschatological expectations, for their part, were joined with the messianic promises, which underwent a decisive transformation and differentiation in late Judaism, especially in the two centuries just before the appearance of Jesus.
Position in the organism and with respect to other cells seems to be decisive in directing differentiation.
In the developing central nervous system (CNS), two basic helix-loop-helix transcription factors, Olig1 and Olig2, are decisive in oligodendrocyte differentiation and maturation.
We show that the conserved Teashirt transcription factors are decisive for the differentiation of a subset of secretory cells, stellate cells, in Drosophila melanogaster renal tubules.
Genotype was a decisive factor for embryo differentiation.
Together, these data indicate that the internal titration of activated cell cycle checkpoints, hormones, and developmental factors, which determine cell competence towards stemness, division, and differentiation are decisive for organ survival following IR.
No significant reduction of the expression of PPARγ, C/EBPα, C/EBPδ and SREBP-1, which play decisive roles in the differentiation of adipocytes [3], were detected in Nscl-2 mutant epididymal adipose tissue although a slight reduction of PPARγ, C/EBPα in ob/ob and in Nscl-2 ×ob/ob compound mutant mice was noted (Fig. 6D).
Antigen-presenting cells such as DCs and macrophages play a decisive role in the differentiation of T-cell subsets into a Th1 or Th2 phenotype.
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