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This phase of the neurogenic process comprises the emergence of the first indications of neuronal or non-neuronal lineage commitment [ 21], being for such reason, a decisive checkpoint in the determination of neural progenitors cell-fate.
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These observations suggest that the QC cannot fulfill positional signaling roles and control of initials fate after IR in atm seedlings, and that ATM likely controls decisive checkpoints for stem cell maintenance.
There were many checkpoints along the way where more decisive action would have eliminated this issue".
Together, these data indicate that the internal titration of activated cell cycle checkpoints, hormones, and developmental factors, which determine cell competence towards stemness, division, and differentiation are decisive for organ survival following IR.
A checkpoint.
Very decisive.
The decisive.
"Absolutely decisive.
Air power was decisive.
It proved decisive.
It can be decisive.
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