Sentence examples for decisive alteration from inspiring English sources

The appearance of these centralized states is arguably the single most decisive alteration in economic, and perhaps in all, history.

The ancestral myths describe a primeval time of creation (or successive creations) followed by a decisive alteration in the conditions of life in the shift from the ancestral to the present human mode of being.

There is now sufficient and well-established evidence that epigenetic DNA alterations play a decisive role in the development of cancer by regulating the transcription of many (tumor suppressor) genes.

An early diagnosis is decisive in order to prevent irreversible structural alterations and systolic dysfunction.

This is surprising because the alteration of system properties can be decisive for the overall dynamics of the land system ([ 16 ], Seppelt, in this issue).

If these changes were decisive, we would have expected to see equivalent alterations in correct choice performance in the AAA and ABA contexts, as both demanded identical motor and procedural adaptation.

Jab1 lies at the intersection of several signaling pathways that are believed to be important in breast cancer cells and may be a decisive influence on the outcome of specific pathway alterations and their cumulative effects on progression.

But only one book had such a decisive impact that I can date to it a profound alteration in my worldview and even behaviour.

In a similar vein, the extensive literature demonstrating that pharmacologic manipulations of the dopamine system are associated with alterations in interval timing [38], [31] is not decisive with respect to the role of the basal ganglia in timing.

Analyses of potential correlations between genetic alterations of Stat6, CDK4 and p27 expression could be decisive in clarifying the role of Stat6 in familial predisposition to certain cancers and/or failure of hormonal therapy.

Furthermore, we show that the early, acute downregulation of Dp71 in normal animals may be an important, decisive step in the development of reactive gliosis, upstream of the physiological alterations.