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It provides evidence that CBA supports the choosing problem by integrating multiple perspectives, creating transparency, separating "value" from cost, and clearly documenting the decision rationale.
Perceptions are as important as reality, and the wrong perception of your decision rationale can derail even the best effort.
Conditional appraisals were identified and the requested data were extracted from the G-BA decision rationale [8].
The G-BA's decision rationale (Tragende Gründe) provides further information on the requested data and the time frame for submission of the updated dossier containing the additional data [8].
Efficacy: efficacy data or specific efficacy endpoint(s) explicitly mentioned in the EPAR or the G-BA decision rationale and/or request listed in the 'conclusions on clinical efficacy' section of the EPAR; data from (randomised) studies.
Safety: safety data or specific safety endpoint(s) explicitly mentioned in the EPAR or the G-BA decision rationale and/or request listed in the 'conclusions on clinical safety' section of the EPAR; data from safety studies (randomised or observational studies or registries).
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Using these estimates, we carry out tests and compare the results for heuristic, pessimistic, optimistic, and Bayesian decision rationales.
Records of decision rationales showed that participants were aware of complexity factors but were unable to cope with them effectively under either feedback format.
Nonetheless, the proposed methodology pursued within this project implies an effect from the twofold selection process, which lies in the differing decision rationales of project participants from the world of science and active policy-making.
The IRAT is useful for identifying key gaps in knowledge, focusing risk management efforts, and providing clear documentation of decision rationales.
Examples of evidence-based decision-making rationale included clinical decision rules such as the Canadian CT Head Rule and the Pneumonia Patient Outcomes Research Team (PORT) pneumonia score.
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