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The decision on continuation of the study was based on the confirmatory test of the primary variable.
Although the diagnosis in such cases can be established by reverse transcriptase PCR (RT-PCR), the clinical challenge in FISH-negative, cytogenetically cryptic APL is in making a decision on continuation of ATRA before the diagnosis is definitively established.
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At the brink of implementing new programs (EU) or decisions on continuation of existing programs (USA), we questioned what the influence of the pediatric exclusivity regulation has been on pediatric drug development.
We investigated potential nonlinear relationships between the biomarkers and time on treatment using restricted cubic splines with three knots at 3, 14, and 21 days, chosen to represent immediate changes, and two subsequent time points at which future biomarker-directed trials may inform early decisions on continuation of trial drug.
While a decision on Moores' continuation or otherwise will likely already have been made, the fixture was deemed important enough for the head coach and his assistant Paul Farbrace to fly straight from Barbados to Dublin via London to prepare the side on Thursday.
This study compared the two protocols to determine if there were significant differences and to allow an evidence-based decision on the continuation or modification of this practice.
Thus, he is left to make his own decision on the continuation of his treatment, based on conflicting advices".
Decision on treatment continuation or discontinuation should therefore always be based on a full assessment of complimentary clinical observations and neurophysiological testing.
Since a decision on the continuation of a pregnancy might follow the diagnostic findings of a prenatal test, it is not desirable to identify VOUS and there are some difficulties dealing with some clinically relevant conditions with variable expressivity or incomplete penetrance.
Rudolf Henke, the chairman of the Marburger Bund, the German doctors' association, said in a statement that the acquittal of Mr. Putz should not be seen as "a license for independent action while making decisions on the continuation of life-sustaining measures".
Such evaluation serves the purpose of improving our understanding of the functioning of market interventions and legitimizes future decisions on the continuation of interventions.
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