Open image in new window Fig. 1 Proposed decision chart for the treatment of femoral non-union.
Following the paper publication of practice guidelines for the management of febrile patients returning from the tropics, we constructed a consultation website www.fevertravel.ch that comprises a decision chart and specific diagnostic features providing medical diagnostic assistance to primary care physicians.
In addition, one is able to record: (i) the pathway followed by the physician through the decision chart, (ii) the diagnostic tests performed, (iii) the initial and final diagnoses as well as outcome and (iv) reasons for non-adherence when the physician diverges from the proposed attitude.
The decision chart starts with general 'knock-out' criteria to identify studies that are deemed not transferable.
The tools could consist of a checklist, toolkit, system, practice guideline, set of criteria, decision chart, or index.
The transferability decision chart was then applied to several international cost-effectiveness studies in the areas of interventional cardiology, vaccination, and screening.
For studies in which modeling adjustments are necessary, the decision chart will also guide the user to identify whether the study results are transferable after adjustments either in a descriptive way (reapply the decision chart) or by doing probabilistic or multivariate sensitivity analysis.
As part of the decision chart mother and child outcomes, in terms of maternal and child mortality and HIV transmission related to the uptake of the PMTCT recommendations, are shown by strategy followed.
As shown in Figure 2, Welte proposed the use of a transferability decision chart that takes into account 'knock-out' criteria, a transferability checklist, and methods for improving transferability and for assessing the uncertainty of transferred results.
Therefore, as shown in the decision flowchart in Figure 3, in order to consider a given sequence as a potential candidate that processes the putative reactions, a preliminary requirement has been introduced in the decision chart so that the enzyme should exhibit promiscuous activity based on the estimations performed by a molecular signature-based predictor (see Methods).
