Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR.
The relative simplicity of microbial genomes and the shrinking cost of measuring their complete transcriptomes has made deciphering structures of gene regulatory influence networks and detecting functional relationships within nearly genomically-complete data sets feasible [ 2- 5].
Having deciphered structures for more than 1100 proteins, most of them bacterial, the Protein Structure Initiative is now looking to the "higher hanging fruit," says Director John Norvell of the National Institute of General Medical Sciences NIGMSS).
Despite the essential role played by myelin basic protein (MBP) in stabilizing the multilamellar structure of the myelin membrane, attempts at deciphering the structure of MPB have so far failed.
He had won the Nobel Prize with James Watson almost forty years earlier, for deciphering the structure of DNA, but his research had taken a hard left turn since then, from genetics to the study of consciousness.
Here, we review recent progress in deciphering the structure, assembly and conformational dynamics of viral genome-delivery tail machines.
In recent years, a number of next-generation sequencing (NGS -based studies aimed at decipheriNGS -baseducture and compostudiesof the aimedys' microbiotat
During the past decade, computational and mathematical methods of systems biology have become effective tools for deciphering the structure and regulation of complex metabolic networks.
The "single-shot" technique marks an important step toward deciphering the structure of proteins by zapping just a single molecule--a potentially revolutionary technique that physicists hope to perfect with the world's first x-ray lasers, currently under construction in the U.S., Germany, and Japan.
Therefore, deciphering the structure and underlying translocation mechanism of T4S systems is crucial to facilitate development of new drugs.
Deciphering the structure and dynamics of the protein-protein interaction (PPI) networks is among the major objectives of the systems biology research in the quest for the mechanisms of life.
