Striving for mechanisms: one goal of the analysis of genetic interaction maps is to decipher the causal explanation underlying the observed interactions.
The broad taxon sampling used in our investigation prevented us from deciphering the mechanisms and forces underlying the observed IR losses, large IR expansions/contractions, and gene rearrangements.
Notably, in this 'kidney-centered' study, parameters (including cardiac output, renal venous pressure, renal interstitial pressure, inflammation parameters, and so on) with potential interest in deciphering the relationship observed between MAP and RBF could not be measured.
The observed markers in the present study are ubiquitously distributed can help in deciphering the gene level regulation.
The observed sexual growth and maturity dimorphism in favour of females adds value towards deciphering the sex determination system of this species.
However, deciphering the Ahr-specific transcriptional response is not a trivial task, considering that Ahr activation might trigger the activation of other TFs or the generation of toxic metabolites which will add side effects to the observed differential gene expression.
These observations indirectly decipher the characteristic trough observed at λ467 556 nm (figure 1) in aging lenses.
However, given the roles of small RNAs to modulate gene expression post-transcriptionally, for example, via miRNA-mediated degradation of target transcripts, it is important to measure both small RNAs and mRNAs at the genome-scale in order to decipher the mechanism underlying observed intercellular miRNA and mRNA heterogeneity.
Deciphering commonly observed patterns and processes within riverine landscapes resulting from the interplay between physical and biological components is a central tenet for the interdisciplinary field of river science.
Comparative sequence analysis employed here provided a better understanding of the host association, evolution of members of the M. avium complex and could help in deciphering the phenotypic differences observed among sheep and cattle strains of MAP.
