To decipher the mode of toxicity by different toxicants, powerful tools such as genomic phenotyping have been developed [ 1, 2, 11- 16].
In this study, we aimed at establishing a reliable functional assay using mitochondria isolated from breast cancer cells to decipher the mode of action of BH3 peptides derived from BH3-only proteins.
In order to decipher the mode of Rage function on gene transcription levels during inflammation, we applied global gene expression profiling on time-resolved samples of mouse back skin, which had been treated with the phorbol ester TPA, a potent inducer of skin inflammation.
The hCMEC/D3 cell line provides a useful model for deciphering the modes of interactions between human brain endothelium and activated immune cells.
Either way, deciphering the modes and mechanisms driving regeneration in multiple model systems will not only help us resolve a long-standing question in biology and evolution, but also have clear ramifications for our understanding of wound healing and regeneration in humans.
Indeed, more work is needed to identify the specific active ingredients, with a view of deciphering the mode(s) of action of the plant compounds.
The new application of Normal Mode Analysis (NMA; Goldstein, 1950) to the protein BPTI deciphered the mode compositions of protein fluctuations (motions in the range <30 cm−1 dominate the fluctuations) and described crystallographic temperature (B−) factors (the degree of uncertainty in atomic positions) surprisingly well (Gō et al. 1983; Brooks and Karplus, 1983).
To date, the recently proposed hypothesis deciphering the mode of action of DBS points toward a functional inactivation of neuronal activity in the stimulated area, and an excitation of direct axonal and fiber pathways near the electrodes that would regulate distant structures (Montgomery and GALE, 2008, Vitek, 2002).
The present study was performed to decipher the P140 mode of action.
In an attempt to decipher the SR31747A mode of action, we found that the two binding sites may not fully account for this activity.
