Further experiments are required to identify the proteins that are involved in the activation of CUn-MepG-containing genes and for deciphering the interplay between those proteins and the MBPs in the regulation of gene expression.
Studying these circuits in intact, normal animals is important to decipher the interplay of excitation and inhibition between different neural circuits for dynamic control of eye movement and gaze control.
Recent studies have tried to decipher the complex interplay between stem cells and niches, and thereafter to engineer SCDS, mimicking dynamic stem cell niches encompassing a wide range of biochemical, biophysical, and biomechanical cues.
A more complete understanding of interphase nuclear structure will require that we decipher the dynamic interplay between each of these influences on chromosome folding under changing environmental conditions.
This point of view, which is quasi-Larmackian [ 47], is in line with a number of recent discoveries that are leading to a new theory of "extended evolutionary synthesis" [ 48], which indeed investigates the impact of both genetic and epigenetic inheritance on evolutionary phenomena in order to decipher the complex interplay between genotypes, epigenotypes, phenotypes and environment.
Deciphering the 'glycosylation code' that dictates the interplay between the nature of the carbohydrates or the proteins and the biophysical properties of the glycosylated proteins is essential.
This chapter provides insights into the interface between transcription and translational networks, and discusses some lessons gained from deciphering the reciprocal interplay between the different regulatory mechanisms.
Simulated datasets with known underlying disease mechanisms have been widely used to develop efficient statistical methods for deciphering the complex interplay between the genetic and environmental factors responsible for complex human diseases, such as hypertension, diabetes and cancer [ 1- 3].
Here in order to decipher the potential mechanism of MSC therapy for cardiac fibrosis, we investigated the interplay between MSCs and cardiac myofibroblasts (mFBs) using interactive co-culture method, with comparison to paracrine approaches, namely treatment by MSC conditioned medium and gap co-culture method.
The mission to decipher our genetic blueprint is being succeeded by a mission to understand the interplay between genetic factors, the environment, and human traits in order to promote health through novel treatments and preventative strategies.
