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Further study using higher resolution assessment of methylation, as well as integration with genome-wide promoter architecture data (such as DNase hypersensitivity and histone modification) is needed to decipher in more detail the regulatory forces causing gene silencing and the likelihood of up-regulating key tumor supressor genes using drugs that target DNA methylation.
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Shiekhattar, who was not part of the research team, adds that important next steps include deciphering in more detail the mechanism of how this lncRNA exerts its effects, and testing what happens when the lncRNA is knocked out in mice.
This serological investigation will provide the foundations for future work aimed at deciphering in more detail the host immune response against SigA, so as to eventually map the specific epitopes implicated in this induction as a prerequisite to the development of vaccines against shigellosis.
It is expressed in villous cytotrophoblasts (vCTBs), promotes proliferation and survival of trophoblastic cells and is a promising target to decipher the molecular mechanisms behind the pathogenesis of PE in more detail.
Furthermore, the puzzling reduction of DNA-binding activity under oxidizing conditions that contradicts the finding that upregulation of WRKY53 expression by hydrogen peroxide partially requires REVOLUTA prompts us to decipher the redox-dependent changes in the REVOLUTA protein outside the DNA-binding domain in more detail.
case in more detail.
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Consider the waiter example in more detail.
But then he explained in more detail: .
See the rules in more detail here.
This was then investigated in more detail.
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