We deciphered in detail the molecular mechanism which directs α-Synuclein into extracellular vesicles which is of highest relevance for the understanding of Parkinson's disease pathogenesis and progression at the molecular level.
Further study using higher resolution assessment of methylation, as well as integration with genome-wide promoter architecture data (such as DNase hypersensitivity and histone modification) is needed to decipher in more detail the regulatory forces causing gene silencing and the likelihood of up-regulating key tumor supressor genes using drugs that target DNA methylation.
For Plasmodium-SERAs, the next challenge is to decipher their function in detail, in particular to define their role in the execution of host cell death.
Shiekhattar, who was not part of the research team, adds that important next steps include deciphering in more detail the mechanism of how this lncRNA exerts its effects, and testing what happens when the lncRNA is knocked out in mice.
This serological investigation will provide the foundations for future work aimed at deciphering in more detail the host immune response against SigA, so as to eventually map the specific epitopes implicated in this induction as a prerequisite to the development of vaccines against shigellosis.
In contrast, the genome sequence of C. elegans has been deciphered in fine detail, clearly representing an added value to comprehensive ecotoxicogenomics.
In recent years, advances in sequencing technologies have enabled the genetic and genomic events that underlie pancreatic carcinogenesis and progression to be deciphered in great detail.
The SNP genotyping platform and procedures have also been described in detail elsewhere (The Deciphering Developmental Disorders Study 2015).
The array-CGH design, experimental procedures, QC, and CNV calling and merging have been described in detail elsewhere (The Deciphering Developmental Disorders Study 2015).
In the present study, we attempted to decipher the detail mechanism of its transcription regulation.
