Since patient recruitment was slower than expected, the sponsor decided to terminate the study at the interims analysis, and no further patients were enrolled.
The DMC recommended that the trial be stopped, and we decided to terminate the study prematurely in August 2006.
Due to a prolonged inclusion period, it was decided to terminate the study when 40 patients had completed the protocol.
Due to a lack of sufficient patient recruitment, the protocol committee decided to terminate the study prematurely.
Finally, after taking into account toxicity, quality/duration of response, patterns of treatment failure and the activity observed with other drugs, it was decided to terminate the study before going into the second stage.
Therefore, the Institutional Scientific Review Board decided to terminate the study early after a subsequent interim analysis revealed a significantly better outcome of patients randomized to group B. Time-to-arrhythmia recurrence was estimated using the Kaplan Meier method and compared using the log-rank test.
In September 2005, after completion of the interim analysis, the steering committee decided to terminate the study with 37 patients enrolled in each arm, because of the unexpectedly high rate of skin toxicity (grade ⩾3) in both arms (32.4% and 18.9% of patients in arm A and B, respectively, Figure 1).
"Mitchell spent three years speaking out against the city, and that was a major factor in deciding to terminate this contract.
The committee can decide to terminate the study because of safety issues.
Around 92% of women who received an antenatal diagnosis of Down's syndrome decided to terminate the pregnancy, and this proportion was constant throughout the period covered by the register.
This was when Bremer decided to terminate the employment of and close down the Iraqi military and police.
