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Moreover, the developed SPR biosensor showed decent selectivity toward miRNA-200 family members.
A three-chambered electrochemical cell was designed, in which CO2 was first reduced to formate electrochemically with a decent selectivity.
It is therefore highly desirable to have a narrow-sized distribution of Pt nanoparticles which exhibits decent selectivity in addition to high conversion.
We reported a novel ethane selective metal organic framework material Ni bdc)(ted)0.5 with a high uptake of C2H6 and a decent selectivity towards C2H6/C2H4 separation.
Noticeably, N4-((2S,3S -3- 3-bromophenyl -4- 4-chlorophenyl butan-2-yl -N6-butylpyrimidine-4,6-diamine (13b) demonstrated good binding affinity and decent selectivity for CB1 receptor (IC50 = 16.3 nM, CB2S,3S -3- 3-bromophenyl -4- 4-chlorophenyl butan-2-yl -N6-butylpyrimidine-4,6-diamine
Noticeably, 2- 5- 4-bromophenyl -1- 2,4-dichlorophenyl -4- 5-methyl-1,3,4-thiadiazol-2-yl -1H-pyrazol-3-yl -5- 1- trifluoromethyl cyclopropyl -1,3,4-oxadiazole (16l) demonstrated good binding affinity and decent selectivity for rCB1 receptor (IC50 = 1.72- 5- 4-bromophenyl -1- 2,4-dichlorophenyl -4- 5-methyl-1,3,4-thiadiazol-2-yl -1H-pyrazol-3-yl -5- 1- trifluoromethyl cyclopropyl -1,3,4-oxadiazole
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Lorlatinib has demonstrated decent kinase selectivity, promising pharmacokinetic profile, selective brain-penetration and strong antiproliferative activity in several ALK/ROS1-driven tumor models.
Moreover, the biosensor displays decent stability, excellent selectivity for different interfering compounds and applicability in real samples analysis.
Furthermore, non-enzymatic H2O2 sensors based on the 3D N-Co-CNT@NG electrode exhibited high sensitivity (28.66 μA mM−1 cm−2), wide linear range (2.0 7449 μM), low detection limit of 2.0 μM (S/N=3), excellent selectivity, decent reproducibility and long term stability.
The most active compounds in this study are two novel molecules, 11 and 16, showing promising selectivity and decent IC50 of 16.2 and 20.1 nM, respectively.
Pleasingly, both the γ-substituted and the β-substituted substrate reacted to give decent yields (50, 72 and 61 %, respectively), with 3 v also providing >20 1 E/ Z selectivity.
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