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These changes are in line with prolonged cardiac relaxation and delayed intracellular Ca2+ decay in response to lethal toxin exposure.
The present research is part of a large-scale field experiment that has demonstrated a significant slowing of plant detritus decay in response to simulated atmospheric nitrogen deposition at a rate expected by 2050 in this region (additional 3 g nitrogen m−2 y−1 to ambient deposition).
Both types of studies identified changes in mRNA synthesis and decay in response to osmostress and identified three phases of the stress response: shock, induction and recovery phases (Miller et al. 2011).
Monitoring the time-course of caspase-2L decay in response to cycloheximide by western blot analysis furthermore indicates that the increase in caspase-2L protein in HuR-knockdown cells does not rely on an elevated protein stability.
Decreased serum insulin and RBG levels and the improved glycemic decay in response to insulin injection in the ChM Group compared to the Ch Group reflected increased peripheral response to insulin, as confirmed by the decreased HOMA-IR.
Phosphorylation of RNA-binding proteins by protein kinases and their dephosphorylation by protein phosphatases is an important on/off switch to control RNA processing and mRNA decay in response to extracellular signals or cell cycle checkpoints.
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These data suggest that, at least for transcripts with more rapid decay rates in fibroblasts, changes in mRNA decay rates in response to arsenite accounted for very few of the steady-state changes observed after 24 hr of treatment.
This pinning was readily substantiated experimentally by the comparison of the current build-up and decay transients in response to small potential steps.
The expression levels of the long ncRNAs were elevated because of prolonged decay rates in response to chemical stressors [ 41].
(A )–(C ) Levels of transcripts controlled by nonsense-mediated mRNA decay (NMD) in response to cycloheximide (CHX) treatment.
Junctional conductance (g j ) measured under steady-state conditions decays symmetrically in response to V j of either polarity, which have been explained by the presence of a V j -sensitive gate in each opposed HC [ 4].
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