Unlike the generic model presented by Mitra and collaborators [ 69], however, here we studied the dynamical behavior of specific genes which have been extensively characterized experimentally during decades of plant developmental genetics studies (see, for example [ 2]).
It has also been suggested, however, that the single gene expression approach of the last several decades of evolutionary developmental biology ("evo-devo") has outlived its usefulness, and that what are needed are not more model organisms, but rather a smaller number of groups chosen for the ability to functionally manipulate genes [ 9, 10].
After more than a decade of intense developmental work, only one antisense drug-Isis Pharmaceuticals' Vitravene, for the treatment of certain rare eye infections in AIDS patients-has won Food and Drug Administration approval.
Decades of progress in developmental cardiology has advanced our understanding of the early aspects of heart development, including cardiomyocyte (CM) differentiation.
Decades of research in developmental biology have revealed the fine balance of transcription factor expression that is required to initiate and maintain cardiac lineage commitment.
And Lawrence says Eisen's desire to order a copy of the 1992 handbook suggests that, despite 2 decades of breathtaking advances in developmental biology, he succeeded at his intention to "write a book that lasts".
This fluent discussion of developmental biology synthesizes decades of intensive progress in specialized areas of the science: from the dramatic deciphering of the genetic code to detailed analyses of animal behavior patterns.
Despite several decades of studies focused upon the developmental impact of PCB exposure upon the female reproductive tract, the molecular and cellular pathways that lead to reproductive tract malformations, dysfunctions, and cancer progression after PCB exposure are poorly understood.
Hox genes have represented one of the major paradigms of developmental biology for nearly three decades (reviewed in [1], [2]).
