Targeted screening for celiac sprue is critical to diagnosing this treatable disease, reversing debilitating morbidity, and preventing neoplastic consequences.
10 Accelerated CVD leads to debilitating morbidity in HGPS and culminates in mortality from myocardial infarction or stroke at an average age of 13 years.
The most debilitating morbidity is chronic lymphedema, which is difficult to define.
Haemoglobinopathies (HbP), such as sickle cell disease (SCD) and thalassaemia, are serious autosomal recessive disorders characterised by severe anaemia, variable but severe and debilitating morbidity and a shortened lifespan.
Cystic fibrosis (CF) is an inherited, rare autosomal recessive disease that results in chronically debilitating morbidities and high premature mortality.
It is estimated that ≤1% of WNV-infected patients will develop neuroinvasive disease (West Nile encephalitis and/or myelitis) that can result in debilitating morbidities and long-term sequelae.
The increased use of hematopoietic stem cell transplantation (HCT) among children, coupled with an increase in survival, has led to a rise in the number of young HCT survivors.[ 1, 2] Osteonecrosis, a debilitating skeletal morbidity[ 3, 4] is one complication that can compromise quality of life among these survivors.
Chronic kidney disease is an increasingly prevalent problem that is debilitating, increases premature morbidity and mortality, and is very costly to manage.
Some forms of CL, particularly diffuse CL and mucosal leishmaniasis (ML) can be severely disfiguring and extremely debilitating, causing significant morbidity and, in some cases, death.
Background: migraine is a severely debilitating desease, causing significant morbidity and negative impact on sufferers' quality of life (Bigal 2008).
Cough can lead to high morbidity and cause debilitating symptoms such as exhaustion, insomnia, hoarseness, musculoskeletal pain, sweating and even urinary incontinence (3,4).
