In addition to ischemic insult, differences in hippocampal vulnerability to stressor induced damage are observed in debilitating age-dependent diseases such as Alzheimer's disease.
Parkinson's disease is a debilitating, age-associated movement disorder.
In this study, Masayo Takahashi, ophthalmologist at the RIKEN Center for Developmental Biology in Kobe, plans to use iPSC-derived cells for the treatment of the debilitating eye disease age-related macular degeneration (http://blogs.nature.com/news/2013/02/embryo-like-stem-cells-enter-first-human-trial.html http://www.nature.com/news/stem-cells-cruise-to-clinic-1.12511).
One of the most striking and debilitating age-associated alterations is the progressive loss of fat-free skeletal muscle mass, a phenomenon known as sarcopenia [4] [7].
Hence, optimistically, we could be looking at better prevention and management of cancer and dementia, two of the most debilitating age-associated human conditions.
As the population ages it is particularly important to understand predisposing factors to debilitating age-related disorders such as cognitive impairment, so that effective public health interventions can be developed.
Extended lifespans mean that a growing number of people are facing debilitating diseases in old age and, as a result, more are ending their lives in hospitals and hospices than ever before.
Diagnosed with debilitating ulcerative colitis at age 6, I have learned to navigate a world of dietary minefields.
What is reviving in America is the old economy that was unsustainable -- Gilded Age inequality, debilitating trade deficits, concentrated and highly leveraged banks, and a declining middle class.
The severity of HFS ranges from being lethal during early childhood to chronic and highly debilitating at a later age.
That's because, he points out, the results show, in essence, that being physically fit "compresses the time" that someone is likely to spend being debilitated during old age, leaving the earlier post-retirement years free of serious illness and, at least potentially, imbued with a finer quality of life.
