Sentence examples similar to debilitated 1 from inspiring English sources

An MDR-TB patient co-infected with HIV is subject to long and potentially toxic treatment that may make the patient debilitated (4), stressed, and de-motivated.

We are left in corridors for hours until a bed is found, we are crammed in like sardines with no sleep and no privacy, midwives arrive and depart around us like the changing of the guards, our labours are overseen by overworked doctors on debilitating 48-hour shifts, there is no food or drink to be had, snap decisions are made over our heads, medical intervention at all stages is the norm.

Depending on the population surveyed, HIV-SN, regardless of previous ARV exposure, has a prevalence of between 13% [12] and >50% [13] [14] of HIV infected individuals, of whom 40% experience severe pain, ≥5/10 Numeric Pain Rating Scale (NPRS), and 90% experiencing some pain, which can be severely debilitating [1].

A third way for PI3K/Akt to debilitate Smad3 is through the inactivation of certain nuclear factors that are necessary for Smad3 function.

In parallel, deregulated c-Myc can also debilitate p53-mediated cell cycle arrest (Vafa et al. 2002) and promote proliferative signaling, which is a hallmark of cancer (Hanahan and Weinberg 2011).

Activity limitation refers to the child's difficulty in performing usual activities; this indicator emphasizes that the functional impact of a chronic condition may or may not be debilitating [ 5, 8, 10, 27].

Moreover, in two of the studies on compensation, it was shown that the compensatory mutations had occurred outside the gene that was debilitated [ 58, 59].

It is unmitigated by rest/sleep and is physically debilitating [ 1, 2].

As shown in previous studies, MitoPark mice begin showing motor impairment symptoms by 12 weeks of age (Ekstrand et al., 2007; Ekstrand and Galter, 2009) and are severely debilitated by 36 weeks due to the significant degeneration of dopamine neurons in the substantia nigra pars compacta, and loss of dopaminergic striatal innervation (Ekstrand et al., 2007; Ekstrand and Galter, 2009).

According to an estimate, there are as many as 8000 ODs, many of which are known to be of genetic origin, affect children at a very early age and are life-threatening and/or chronically debilitating [ 2, 3].

Azoarcus structures additionally include either the 3′-exon intron junction (substrate of the second step) or the ligated exons and are debilitated by 2′-deoxy substitutions at various positions or lack the scissile phosphate.