These findings led to the still debated hypothesis that MGMT promoter methylation associated with negative MGMT protein expression may be a good prognostic factor in GBM patients.
The first example is a hotly debated hypothesis that emerged from research on the role of salt retention in heart disease in African Americans beginning in the 1980s.
The high frequency of PTEN LOE and the low occurrence of PIK3CA mutations in TNBC with basal-like features might bring support to the still debated hypothesis of the mutual exclusivity of these two alterations [ 14, 15].
The number of institutes worldwide with increasing sequencing capacities has been rising at an exponential rate and the first results of analyzing such data have solved old and long debated hypotheses and also have generated breakthrough ideas that have opened new avenues in all fields of genetics and evolutionary biology.
Want in-depth examples of how scientists debate different hypotheses regarding human evolutionary history?
Others have debated this hypothesis since these plaques can persist despite resolution of the infection and treatment with steroids [4].
The biological mechanism underlying these shifts has been a matter of debate, with hypotheses falling into two camps: (1) the shift is driven by changes in host abundance, or (2) the shift is driven by seasonal changes in the foraging behavior of mosquitoes.
We intend to publish the following types of contributions: original research, reviews, commentaries, debate articles, hypotheses, methodology articles and short reports.
Although the academic debate surrounding this hypothesis has not yet been settled, there is strong evidence that rapid warming or cooling episodes have caused multiple mass extinctions of other species over the past 500 million years.
From this debate, an emerging hypothesis is that mesophication and increases in the abundance of mesophytic genera (e.g., Acer, Betula, and Fagus) resulted in forests that are more vulnerable to drought.
Part of the debate over the hypothesis during the last dozen years has centered on determining the best orbital analog to the Holocene among prior interglaciations, all of which must have been natural (non-anthropogenic) in origin.
