However, it is valid to compare MCID on general cognitive measures when assessing interventions that aim to improve cognitive function, and therefore taken simply on general cognitive grounds alone, cognitive interventions remain of debatable clinical significance.
It is possible that in larger studies a significant difference could be achieved, but whether this would be of clinical significance is debatable [ 64].
Overall pain scores were still significantly higher in the office group than in the inpatient group but these differences were small and so their clinical significance is debatable; differences between groups in the amount of postoperative medication may also have affected this to an unknown degree.
While the exact manner of their origin and current functional significance is debatable, it is apparent that TA systems have arisen via HGT in a wide range of bacteria [168].
Whether mere mucosal or sub-mucosal inflammation, as will be reported commonly in the histology of removed appendixes for uncomplicated appendicitis, is of any clinical significance is debatable.
Despite growing evidence implicating roles for particular molecular markers and pathways in the initiation and progression of osteosarcoma, their clinical significance remains debatable.
Furthermore, the result is an increase by 1 or 0.5% of the proportion of unmethylated (possibly F3-expressing) cells from a baseline of 95.5 98% and 98 99% (Table 4), respectively, a change whose significance is debatable.
This prognostic significance is debatable due to the small number of patients (Sedmak et al, 1989; Byrne et al, 1992), the short median follow-up (Hainsworth et al, 1993), and to the fact that IHM were detected not only by immunohistochemistry but by a combination of morphological analysis on haematoxylin-stained slides and immunohistochemistry (McGuckin et al, 1996).
Its significance though is debatable.
Hence, its significance is still debatable, but it is an interesting area and may be explored in future studies.
Although this suggests that Etest may not be effective in detecting weak synergy, it is debatable what, if any, clinical significance detection of such activity may have.
