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Our previous data indicated that DT-GMCSF induced cell death was dependent on the adaptor protein FADD [10].
This germ cell death was dependent on the apoptotic machinery, as no dying cells were detected in ced-3 or ced-4 mutant animals (Figure 7)[27].
The cell cycle arrest in AECHL-1 treated MCF-7 cells was followed by concentration dependent apoptosis, but the percentage of cell death was dependent on the types of cell lines.
In order to examine whether H35N induced cell death was dependent on caspases, cells were left untreated or treated with the pan caspase inhibitor zVAD-fmk followed by H35N treatment and the cell death was assessed by trypan blue staining.
Interestingly, the extent of cell death was dependent on the developmental stage at which plants were transferred under LD: the older the plants at the time of transfer, the fewer lesions were observed on leaves.
Nonetheless, we found that HMDM and J774A.1 cell death was dependent on YopJ/YopP expression as indicated by severe membrane disruption and release of cytosolic components (Fig. 1 and Fig. 2).
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Taken together, the current data indicate that dimerizer-induced cell death is dependent on the presence of the iCasp9 construct, but the effectiveness does not depend on upstream signalling molecules in the apoptosis pathway like Bax and Bak.
As such, these data imply that lidocaine-mediated cell death is dependent on mitochondrial function.
NO-induced loss of MMP and apoptotic cell death are dependent on caspase activity.
Pyroptosis, one such form of cell death, is dependent on inflammasome activation.
Since several data suggest that TSPO ligands may act as chemotherapeutic agents, in this paper we also demonstrate that TSPO ligand-induced cell death is dependent on TSPO density.
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