Gaudí died after being hit by a tram in 1926, with the project only about one-quarter complete, and for decades after his death, progress was slow, sporadic and often intensely debated.
GPR17 labeling in the lesioned area decreases as cell death progresses.
It is thus tempting to propose that apoptotic death progresses during metacyclogenesis in the vector and that due to the temperature change occurring during insect to mammalian host passage, the number of PS-exposing promastigotes increases at the inoculation site.
On the other hand, p53-targeting genes (PUMA, AEN, BAX and MAGED1) and death receptor genes (FAS and TNFRSF10B) involved in glioma cell death progress were upregulated.
Variation in ICU admission policy, capacity, and workload may mean that the chances of death progressing to organ donation differ between units.
This is in line with the fact that cellular death progresses with time, i.e. following PMCAO the volume of ischemic brain tissue increases to cover almost the entire right hemisphere by 24 hours.
In apoptotic cells this cyclic process of bleb formation and retraction can occur over sustained periods, and as programmed cell death progresses blebs may become packed with cellular organelles and condensed chromatin to form the basis of fragmentary membrane-clad apoptotic bodies.
Live/dead assays across the gel revealed a "zone of death" that progressed from the MNPV-containing region, with the closest cells dying within 12 h, followed by cell death throughout the gel after 24 h.
With escalating imatinib doses, the process of cell death rapidly progressed.
