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Similar values were obtained in GFP-HX1 (8.3% and 66.1%) and 88GFP-HX1 cells (8.6% and 65.4%) (Fig. 4), which indicates that the VP88GFP expression does not alter the cell death profile and pathways.
Very intriguingly, for certain stressors, the cell death profile of Y516F mutant was similar to that of R580A.
The cause of death profile, classified into five groups, is presented in Table 1.
The samples were then analyzed for the cell cycle profile and the cell death profile using a Becton Dickinson Instrument.
Hence, these data appear to replicate closely the cell death profile of the drug observed in preclinical models (Sheng et al, 2004; Rice et al, 2011).
Both treatments resulted in a different cell death profile from the CQ-induced pathway and zVAD was unable to inhibit these features.
Similar(52)
The cause of death profiles were similar in both settings with infectious diseases, haemorrhage and malaria accounting for half the deaths.
As a result, TH may improve survival by suppressing death profiles and promoting survival profiles.
Both sodium azide and heat treatments resulted in distinctly different cell death profiles compared with CQ-induced cultures.
To exclude false positives due to cytotoxicity, we tested cell proliferation, apoptosis, DNA damage, and cell death profiles by high-throughput microscopy (HTM).
We have previously shown that using a standard model across a wide range of settings yields appreciably different, and plausible, cause of death profiles (28).
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