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Deaths occurred either at the end of the viremic phase (4 deaths on day 9 and one on day 10), or at the height of viremia (one death on day 11 with the monkey serum virus), or in the post-viremic phase (one death each on day 14, 20, and 21).
The group of mice administered 0.25 mg/kg Bortezomib showed one death on day 3 and a total of nine deaths by day 9 (Table 1).
For the SMT19969-treated animals, there was one death (on day 2) in the 50-mg/kg dose group (n = 20), two deaths (on day 11) in the 20-mg/kg dose group (n = 20), and two deaths (on days 4 and 12) in the 10-mg/kg dose group (n = 10).
Seven deaths were attributable to melioidosis, whereas the eighth case had both tuberculosis meningitis and B. pseudomallei pneumonia and had responded to 14 days of ceftazidime by the time of death on day 23 because of intracranial hypertension secondary to tuberculosis meningitis.
Patient 4 evolved to brain death on day 1 and was then excluded.
The occurrence of a systemic inflammatory response, in particular an acute respiratory distress syndrome (ARDS), appears to be the primary cause of death on Day 3 in trauma patients [12].
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