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Taken together, the current data indicate that dimerizer-induced cell death is dependent on the presence of the iCasp9 construct, but the effectiveness does not depend on upstream signalling molecules in the apoptosis pathway like Bax and Bak.
Pyroptosis, one such form of cell death, is dependent on inflammasome activation.
Open image in new window Figure 6 HEC23-induced cell death is dependent on the STAT3-cathepsin pathway.
Since several data suggest that TSPO ligands may act as chemotherapeutic agents, in this paper we also demonstrate that TSPO ligand-induced cell death is dependent on TSPO density.
We then demonstrated that H2O2-induced cell death is dependent on Tah18 abundance in the cell.
METH-induced cell death is dependent, in part, on activation of endoplasmic reticulum (ER -dependent dER -dependent [11].
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Our previous data indicated that DT-GMCSF induced cell death was dependent on the adaptor protein FADD [10].
It was found that the level and speed of macrophage cell death were dependent on the infection doses of rough Brucella.
This germ cell death was dependent on the apoptotic machinery, as no dying cells were detected in ced-3 or ced-4 mutant animals (Figure 7)[27].
The cell cycle arrest in AECHL-1 treated MCF-7 cells was followed by concentration dependent apoptosis, but the percentage of cell death was dependent on the types of cell lines.
In order to examine whether H35N induced cell death was dependent on caspases, cells were left untreated or treated with the pan caspase inhibitor zVAD-fmk followed by H35N treatment and the cell death was assessed by trypan blue staining.
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