Sentence examples for death in solid from inspiring English sources

The induction of cell senescence appears also to be the critical mode of cell death in solid tumors during chemotherapy or radiotherapy.

Arsenic trioxide (As2O3), which can kill hematological tumor cells via apoptosis, induces autophagic cell death in solid tumor cells by up-regulating the expression of Bnip3 [45].

However, the initial enthusiasm for using PI3K, Akt, or mTOR inhibitors as antineoplastic agents has been tempered by observations that such inhibition typically promotes growth arrest rather than cell death in solid tumors [ 19].

Specific inhibitors of Chokα promote apoptotic cell death in solid tumors and leukemic T cells, whereas the viability of normal primary cells is not affected, indicating the therapeutic potential of targeting Chokα in cancer treatment.

Exposure to proteasome inhibitors for as little as one hour can suffice to consign MM plasma cells to an apoptotic fate, whereas much higher levels of drug or longer exposures are normally required to induce cell death in solid tumor cells [ 25] and possibly in MM stem cells that are at an earlier developmental stage [ 38].

For example, only simultaneous knockdown of both Hsp72 and Hsc70 was able to induce cell death in solid tumour cell lines [34], yet in the case of MM cell lines we were able to induce cell death by a single knockdown of Hsc70, consistent with Hsc70 playing a potentially more important role in MM survival.

Metastasis, the foremost cause of mortality in cancer patients, accounts for more than 90% of all deaths in solid tumour diseases, but the underlying mechanisms remain elusive.

Metastasis, as opposed to tumor growth, is the major cause of cancer mortality, accounting for 90% of deaths in solid neoplasias [ 1], such as breast cancer.

Breast cancer metastasises though the lymphatic system or via the circulatory system and is the overwhelming cause of mortality in patients with malignancies, causing 90%% of deaths in solid tumours [ 53].

Although radiation is known to induce apoptosis, yet it accounts for a minor portion of cell death in irradiated solid tumors [7], and our recent study showed that knockdown of pro-apoptotic proteins Bak and Bax resulted in an increase in lung cancer radiosensitivity in vitro [8].

The metastatic disease rather than the primary tumor itself is responsible for death in most solid tumors, including breast cancer.