To verify the functional involvement of caspase-2 in RGC apoptosis in the ONC model, and to explore the possible protective effects of caspase-2-targeted siRNAs in ON damage models of RGC death, we designed a chemically modified synthetic siRNA targeting caspase-2 (siCASP2) that is capable of inhibiting both the human and rat caspase-2 orthologues.
Saint-Gaudens, before his 1907 death, designed the eagle and double eagle, which entered circulation that year; the cent, quarter eagle, and half eagle were designed by other artists and released into circulation by 1909.
ADS analysed the GPRD data for cause of death, designed the Freetext Matching Algorithm, and manually annotated the results of analysis.
They were greatly inspired by the Gothic Revival, spawned largely by the writing and architecture of A. W. N. Pugin, who was by then working himself to death designing and building the neo-Gothic Houses of Parliament.
When David Álvarez ceded ownership of El Enebro to his children after their mother's death in 1986, he designed a side contract that left him with majority voting rights at the company.
Szyk became a fervently patriotic American; just before his death, in 1951, he designed a calligraphy version of the Declaration of Independence with Revolutionary War troops surging through the text.
He should know: he has history with death-ray buildings, having designed a hotel in Las Vegas with a similar concave facade that scorched sunbathers' hair and melted poolside loungers.
But it should have come as no surprise: it was the second project by architect Rafael Viñoly to wield a death-ray, after he designed a hotel in Las Vegas that melted pool loungers and scorched sunbathers' hair.
The brutality of these ladies' deaths, designed by you to evade discovery, showing the coldness with which you dispatched them, is appalling.
Indeed, the ignition of anticancer immunity is as important as tumor cell death in designing an optimal cancer therapy [ 12, 40, 166].
