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The crystal structures of two PTPN4-PDZ/peptide complexes allow us to pinpoint the main structural determinants of binding and to synthesize a peptide of high affinity for PTPN4-PDZ enhancing markedly its cell death capacity.
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I had done this before, never in a life-or-death capacity, in training.
However, cell death in the NLS-R580A transduced cells was similar to that observed in control cells indicating that localization of TG2 to the nucleus prevents it from acting in a pro-death capacity.
But Scott Johnson's men could do little more to break down the well organised home defence, and when Care burrowed over at the death, a capacity crowd celebrated another encouraging victory.
Proposed improvements to death registration capacity, both globally[ 67] and in China,[ 66] may minimize future uncertainty regarding CHD mortality.
Tracking three cell-level kinetics – cell death, proliferation capacity and migration rate – in a simulated cancer cell population composed of cancer stem and non-stem cells, we show how they interact to produce emergent population-level effects.
In line, the data presented in this study suggest that the cell death inducing capacity of TRAIL is regulated at many different steps and that besides the proper DISC formation, p53 itself has a major impact on the TRAIL efficacy.
For five years they've kept coming — 200 at last count, written by 14 men serving time in the Donaldson Correctional Facility, a maximum-security prison with a death-row capacity for 24 inmates outside Birmingham, Ala.
The forager population grows until resource depletion reaches the point where births replace deaths (carrying capacity).
Although the induction of gene-activatory signalling is the major role of TNF, its cell-death-inducing capacity was the function that gave this cytokine its name in 1975 123.
To create drugs, researchers typically begin with a simple cell behavior — say, its growth or death, or its capacity to change shape.
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