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We find again that the YNG network is over-enriched in apoptosis, programmed cell death, and maintenance of homeostasis.
Components of this putative interaction network are associated to development, DNA repair, cell division, calcium release, cell death, and maintenance of cell integrity.
These findings suggest that a key function of HIF2 α in developing embryos is related to inhibition of neural progenitor cell death and maintenance of neural differentiation through the functions of downstream survivin orthologues.
The tumor protein 53 responds to numerous stresses, including DNA damage, by modulating gene expression leading to enhanced DNA repair, control of cell cycle and cell death and maintenance of cellular homeostasis.
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In contrast, the sGBM only list is enriched for genes that affect cell death, survival and maintenance pathways that would need to be altered or abrogated for tumorigenesis.
This was further observed when comparing the functions of genes commonly hypermethylated in grade IV sGBMs compared to grade IV pGBMs with sGBMs preferentially hypermethylating genes involved in cell death, survival and maintenance pathways and pGBMs preferentially hypermethylating genes that alter or control gene expression.
Since UBC is involved in ubiquitination, it is responsible for cell death and general maintenance.
Therefore, the progression towards T1D derives from the imbalance between increased β-cell death and deficient maintenance of β-cell mass.
It inhibits self-tolerance mediated by IL-2 mediated activation-induced cell death and facilitates maintenance of CD8+ memory T-cell survival including that of self-directed memory cells.
While explants diced into small pieces accentuate cell apoptosis and matrix degradation, the large explants used here minimize cell death and enable maintenance of normal matrix metabolism; thus, native collagen architecture is retained away from the cut edges of the disks.
The top two functions (N1 and N2), associated with the highest score network, were 'Cell death, cellular function and maintenance, hematological system development and function' and 'Cell death, cellular development, cellular growth and proliferation'.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com