Sentence examples for death activation from inspiring English sources

One proposed model to explain BNip3 function posits that BNip3 can exist as an inactive, latent monomer, which requires a death activation signal to become active.

However, accruing evidence points to multiple implications of this enzyme in cell signaling through mitogen-activated protein kinase (MAPK) and oncogene-activated protein kinase pathways, programmed cell death, activation of immune cells, and stem cell differentiation ([ 13- 19] and references therein).

Intracellular mechanisms involved in cell proliferation and cell death (activation of caspases 3 and 7, and decreased histone deacetylase activity), have been extensively evaluated using in vitro assays (Aoyama et al, 2010; Tang et al, 2011a).

Measured responses included activation of ERK and JNK, mitogen-activated protein kinases involved in cell growth, proliferation, and apoptosis (programmed cell death); activation of caspases 8 and 9, enzymes that also are involved in apoptosis; and release of prolactin, a hormone that helps regulate hundreds of biological functions, including metabolism, reproduction, and lactation.

We propose that both abnormal cell death activation and decreased natural neuronal regeneration can contribute to the neuronal loss associated with aging, and perhaps even with that occurring in some neurodegenerative diseases.

But this process is important because "if the apoptotic cells are not properly cleared … it will affect the cell death activation" in organisms like worms and cause persistent inflammation and autoimmune responses in humans.

In injured adult rat motor neurons, apoptotic stimuli induce Hccs translocation outside the mitochondria resulting in suppression of the X-linked inhibitor of apoptosis (XIAP) protein, and subsequent cell-death activation (Kiryu-Seo et al, 2006).

Noteworthy, the latter principle not only allows potent TRAIL death receptor activation but also makes this activation dependent on cell surface antigen binding.

The best characterised signalling activity of Bid takes place following death receptor activation.

Protracted high cdk1 activity has been mechanistically linked to cell death through activation of various death pathways.

In case of death receptor activation, the propagation of the apoptotic signal is enhanced by caspase-8 mediated activation of Bid [ 46].