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These six RNA segments exhibited a great deal of sequence diversity and no homologous sequences were observed between Alaska and California (Table 1).
The human polyomavirus genome displays a great deal of sequence variation, not only between JCV and BKV but also within the various subtypes [ 52].
For example, in a comparison of closely-related species, say human and chimpanzee, one expects a great deal of sequence similarity.
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A key goal of 1000 Genomes Project is to investigate the genetic contribution to human disease by characterizing the geographic and functional spectrum of genetic variation on a great deal of sequencing data [ 10].
A great deal of expressed sequence tags (ESTs) sourced from the suppression subtractive hybridization (SSH) library of C. lunata revealed a similar trend that C. lunata has high sequence similarities with S. turcica and P. tritici-repentis [ 4], which would allow us more efficiently and more easily to find novel functional factors or mechanisms in C. lunata for attacking host plants.
It is now clear that the genome is highly dynamic, involving a great deal of rearrangement where sequences are duplicated, deleted, inserted, inverted or translocated [ 17].
A normalization step is required in these analyses to deal with mapping of sequence reads to multi-copy loci (discussed in detail in 'Materials and methods'); however, the same differences were observed with no normalization or a different normalization scheme.
Additionally, our comparison of regional samples revealed a great deal of previously undiscovered sequence polymorphism, indicated by dark grey boxes in Figure 1.
Since our approach allowed for a great deal of half-site sequence variation, a filtering or refining step was needed to reduce false-positives.
However, a significant result of our test was that the comparison of regional samples revealed a great deal of previously undiscovered sequence polymorphism, indicated by dark grey boxes in Figure 1.
Among a variety of methods, recently emerged recurrent neural network (RNN) is considered more effective to deal with such kinds of sequence annotation problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com