It is on par with calling the dead "life impaired".
Cohort members who were ultimately diagnosed with PD or parkinsonism, dead, cognitively impaired, or seriously ill were not eligible to be controls.
Meticulous monitoring of anaesthetised animals is essential as failure to detect warning signs of impending disaster results in a dead or impaired animal [ 151, 152].
This conclusion is based on the observation that experimental elevation of apoptotic cell load at the wound site resulted in increased inflammatory response; and iii) impaired dead cell clearance activity in diabetic wound macrophages compromises resolution of inflammation in diabetic wounds.
In our studies, autophagy and apoptosis are induced in parallel during mammary involution and whole organ or MEC-specific Atg defects transiently delay mammary gland remodeling due to impaired dead cell clearance after the peak of autophagosome formation and without affecting apoptotic rates.
In the OV, the combination of increased cell proliferation without mitosis, accumulation of dead cell bodies and impaired neurogenesis cause the remarkable phenotype in the OV, including the accumulation of dead cells.
In sum, this study provides first evidence that macrophages from diabetic wounds suffer from impaired in dead cell clearance activity as one of the key factors resulting in increased apoptotic cell burden at the wound site.
In vitro, ATG (BECN1 or ATG7) knockdown compromised MEC-mediated apoptotic body clearance in association with decreased RAC1 activation, thus confirming that, in addition to the defective phagocytic processing reported by other studies, ATG protein defects also impair dead cell engulfment.
Inactivation of genes coding for autophagy proteins, Becn and Atg7, impairs clearance of dying MECs during involution; it was reported that Mgfe8-binding integrin Itgb5 and MerTK are poorly expressed in these mouse models, explaining impaired removal of dead corpses.
Vdphys is increased in acute respiratory distress syndrome (ARDS), and a high dead space fraction represents an impaired ability to excrete CO2 because of any kind of V/Q mismatch.
In addition to impaired clearance of microbes, impaired phagocytosis can cause insufficient clearance of dying or dead cells and lead to pathological inflammation.
