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The concept of balance in the quadrant model predicts that significant activation of the left frontal region may lead to compensating deactivation of the right frontal region.
As shown in Figure 3A, overfeeding resulted in significantly greater deactivation of the right insula (t(1,75) = 3.13, p = 0.049), right inferior visual cortex (t(1,75) = 3.08, p = 0.025), and hypothalamus (t(1,75) = 3.47, p = 0.017) in thin as compared to RO individuals (EU>OF Thin>RO:H>O).
This was evidenced by significantly increased deactivation of the right hippocampus between scans in our control group.
Patients with right TLE showed increased deactivation of the right posterior hippocampus though this was related to less improvement in task performance.
Compared to controls, the right TLE group showed greater progressive deactivation of the right posterior hippocampus 12 months postoperatively compared with 3 months.
Between 3 and 12 months after surgery, patients with left TLE showed increased deactivation of the right anterior hippocampus and this was related to improved performance.
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The right M1 showed more prominent deactivation as the frequency of the right hand increased.
Individuals with left TLE had impaired working memory performance compared with controls and showed reduced activation of the bilateral parietal lobes and greater deactivation of the left posterior and right anterior hippocampus.
These behavioural differences were accompanied by a stronger deactivation in the right parahippocampus during a working memory 2-back task [ 25].
The HRF+TD map showed deactivation in the right frontal, right parietal, and left frontal lobes and was classified as Discordant.
Between the baseline and 3 months postoperatively, the right TLE group did not increase the deactivation of the left inferior parietal lobe or the right inferior parietal lobe to the extent that was seen in the controls.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com