Sentence examples for deactivated mutant from inspiring English sources

Moreover, overexpression of BktB (encoding the second β-ketothiolase with broad substrate specificity) enhanced the (R -3HH-CoA synthesis pathway in the phaA deactivated mutant of C. necatoR -3HH-CoAting the condensation of acetyl-CoA and butyR -3HH-CoAto 3-ketohexanoyl-CoA.

Thus, at the organ level co-expressing an activating and deactivating mutant allele could produce a less severe phenotype than either allele acting alone.

Interestingly, a combination of a CM myofilament deactivating mutant, troponin C G159D, together with an activating mutant, cTnIR193H, produced a hybrid phenotype that blunted the strong activating phenotype of cTnIR193H alone.

These results also underscore that the primary outcome for double heterozygous patients may not necessarily cause a worsening of the disease phenotype particularly in cases where the genotype produces an activating and a deactivating mutant myofilament protein.

Using experimental data from activating and deactivating sarcomeric CM mutants obtained here and elsewhere as foundations, a working model was developed to promote predictive insights into myocyte function of the theoretically possible tens of thousands of compound CM combinations.

As presented in Figures 7d and e, LC3-II expression and autophagosome formation were promoted after selenite treatment when p53 was deactivated in cells transfected with a plasmid encoding a mutant p53 (p53MT).

Therefore suppressing ACKr (or equivalently PTAr) in a mutant lacking Methyl coenzyme reductase (and consequently, the methane forming branched pathway) ensures that both energy yielding pathways are deactivated thereby halting growth.

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