There were eight non-colonized patients who empirically received linezolid or daptomycin, and two of the three patients that could be de-escalated were de-escalated.
There were 27 colonized patients that empirically received linezolid or daptomycin and two of the four that could be de-escalated were de-escalated.
Evidence from available studies did not allow us to elicit any findings on whether a situation is more likely to be de-escalated or escalated in particular settings as a result of an alarm being triggered overtly or covertly.
A presumptive identification and susceptibility profile was obtained at 4 hours, based upon which the investigators recorded a decision as to whether the patients' antibiotics could be escalated, de-escalated or remain unchanged.
Using an a priori decision-making algorithm, the challenge dose will be escalated or de-escalated to achieve the target attack rate, with the aim of reaching the study end point while exposing as few individuals as possible to infection.
Individual characteristics may influence the kinetic parameters (pharmacogenetics): in the case of hydralazine, fast or slow metabolism is genetically determined, and in some studies, doses have been escalated or de-escalated according to individual metabolic parameters [ 57– 57].
They have escalated rather than de-escalated the situation," he told the Guardian from Nicosia.
In the CAPIRI-Bev comparator arm, treatment may be de-escalated to Cape-Bev and re-escalated to CAPIRI-Bev according to a predefined algorithm.
"Instead of escalating the situation, he should have de-escalated," the juror said.
If two or more DLTs occur, escalation stops and the dose is de-escalated to the next lower level (Chin and Lee, 2008).
Kerry: "I come here today at the instruction of President Obama to make it absolutely clear that the United States government would rather see this de-escalated.... "But if Russia does not choose to de-escalate... then our partners will have absolutely no choice but to join us" to expand on steps to isolate Russia politically and economically, Kerry says.
