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Production caused fibre draw down ratios (DDR) from 1 to a maximum of 54 resulting in fibre diameters from 0.7 mm down to 0.07 mm were used.
However, their relative contributions are still unclear given that they share many common substrates, including γ-H2AX, and operate at different levels of the DDR, from break detection to signal transduction.
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Telomeres do not, as might be expected, exclude DDR proteins from chromosome ends but instead engage with many DDR proteins.
The first evidence that PP2A might play a role in the ATM-dependent DDR came from the finding that the PP2A B subunit dissociates from the PP2A heterotrimer in the nucleus in an ATM-dependent manner after IR [ 102].
Another link connecting FUS and DDR came from two reports on the interaction of FUS and HDAC1.
"Our experiments establish the feasibility of using machine learning to automatically generate high-quality DDR charts from raw audio," say Donahue and co.
We review the evidence for the involvement of numerous other protein kinases in the DDR, obtained from documentation of specific pathways as well as high-throughput screens.
One way to ensure that telomeres do not activate DDRs would be to exclude DDR proteins from telomeres.
The first evidence of the primary role of ATM in DDR came from the study of AT patients.
We reasoned that the enhancement of DDR resulting from Wip1 downregulation could facilitate the p53 transcriptional activity leading to a more robust response.
Perhaps the major reason is simply that it would be too difficult to exclude DDR proteins from telomeres given the clear requirement that DDR proteins have high-affinity for DNA damage elsewhere in the genome.
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