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The DCIS rate in the study in Singapore was 26%% [ 6], 30 % in Japan [ 7] and 28 % in Hong Kong [ 8].
In the two screening groups, there were three in-situ cancers compared to 10 invasive cancers (DCIS rate of 23.1 %) The biopsy rate in the opportunistic screening group was 2.3 %, while it was 5.4 % in the targeted screening group.
It is interesting to note that in the diagnostic group, there were only two women with ductal carcinoma-in-situ (DCIS) compared to 79 with invasive cancer (DCIS rate of 2.5%%).
Similar(57)
‡Person years for calculation of breast cancer rates; person years for calculation of combined breast cancer and DCIS rates were slightly lower and are not reported here.
‡Person years for calculation of breast cancer rates; owing to censoring at first breast cancer or DCIS, person years for calculation of combined breast cancer and DCIS rates were slightly lower and are not reported here.
The study group excess in DCIS rates peaked at 6 to 7 years and was balanced by a deficit in invasive tumours at 8 to 9 years, with the screening of the control group.
†Numbers of breast cancers included in calculation of breast cancer rates; when combined breast cancer and DCIS rates were calculated, some of these cases were excluded because women had previously been diagnosed as having DCIS and were consequently censored at that point in time.
However Hagen compared the combined MRI and mammography to the previous mammography only protocol in the BRCA1 carriers and showed very similar DCIS rates and node negative rates (16%, 8% and 26%, 27% respectively) but fewer pT2 tumours detected by MRI compared to previous mammography alone[ 8 ].
Most studies comparing the two technologies have detected an increase in DCIS detection rates with FFDM [ 2, 4, 6, 7, 9, 12].
In a review of large clinical trials on the treatment of DCIS, the recurrence rate is approximately 30% with surgery alone but approximately 15% with the inclusion of radiation.
Our finding that, after 183 months, the absolute ipsilateral event rates are not DCIS grade dependent is in keeping with Solin et al (2001) (median follow-up 9.4 yr range 1 19 yrs) but contradicts Bijker et al (2001) (5.4 yrs), Nakamura et al (2002) (105 months), Kerlikowske et al (2003) (77.9 months) and Pinder et al (2010) (5.7 yrs).
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