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A DC contact capacitive shunt switch on low-resistivity Si substrate is designed and demonstrated.
The contact between the metal bridge and the center conductor becomes DC contact when the metal bridge is driven down.
In terms of the proposed model, followed values were calculated: concentration dependence of the electrical conductivity σ dc, contact electric resistance R к, and number of uninterrupted chains N * chain_in_CM (see Fig. 6, Table 3).
Previous imaging studies in the lymph node utilizing fluorescent 'cell-tracker' dyes have visualized skin-draining DCs carrying cognate antigen, and the associated dynamic changes in T cell motility induced by DC contact [9] [12].
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Once the infected DC contacts CD4 T cells, the large portion of HIV residing in the vesicular caves is transferred to the T cells by expulsion into the virologic synapse at the contact region.
Infection of DC via infected T cell is dependent on T cell-DC contact and is independent of viral envelope and DC-SIGN.
Here, we confirm the involvement of HMGB1 in NK-dependent DC maturation during NK-DC contact, as shown by the inhibitory effect of anti-HMGB1 antibodies or glycyrrhizin, known to interact specifically with HMGB1 [32].
It is not clear whether a single T-DC contact is required to result in T cells anergy or several rounds of contacts are needed within this time period.
CD85j+ NK cell-control of HIV-1 replication was apparently independent of NK cell cytotoxicity or release of soluble anti-viral factors, required NK-DC contact and might involve CD85j+ interaction with non HLA class I ligands.
In support of that is our demonstration that reduction of the number of MHC-peptide complexes presented by DCs to naïve CD8+ T cells decreases both the duration of T-DC contact and the number of productive interaction as measured by the rate of T cell engulfment by DCs.
In addition, Kleindienst et al. demonstrated that viable vaccinal DCs that migrate to lymph nodes transfer their antigens to lymph node-resident DCs by direct DC-DC contact.
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