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On a subcutaneous murine BT474 xenograft model, superior control of tumor growth is demonstrated by targeted pH-triggered vesicles relative to targeted DSPC/cholesterol-based vesicles (35% vs. 19% decrease in tumor volume after 32 days upon initiation of treatment).

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The administration of nutritional supplement was started 7 days before and continued daily upon initiation of patupilone treatment during the entire course of therapy.

Blood was sampled from 44 patients with septic syndrome due to ventilator-associated pneumonia on days 1, 3, 5 and 7 upon initiation of symptoms.

Interestingly, PKD3 mRNA expression exhibited different kinetics during differentiation of C2C12 cells: PKD3 mRNA was only slightly induced upon initiation of differentiation and during mid stage differentiation, but peaked at day 6 of myotube differentiation (Figure 1E).

Upon initiation of DDC treatment, oval cells emerged in the periportal areas by 7 days (Figure 5C) and continued to expand, reaching a peak between 3 and 4 weeks (Figure 5E, G).

Betamethasone (235 mg) was used upon initiation of cardiopulmonary bypass (CPB).

Systemic CS was tapered immediately upon initiation of the first dose of sirolimus.

Propophylatic laser retinal photocoagulation performed 14 days after initiation of antiviral therapy.

The initial SAT was modified for 142 (48.8 %) patients with PIC, 4.77 ± 4.01 days after initiation.

Tracheotomy is performed, anyway, within 14 days after initiation of invasive mechanical ventilation in all patients.

Blood cultures were collected 3 days after initiation of antibiotics and were without bacterial growth.

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