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Levels of 109.3, 146.4, and 130.3 μg/ml were determined for the same time points on day 5 following the 5 days of dosing.
The vehicle control (n = 18) received 100% DMSO (dimethyl sulfoxide) the treated group (n = 8) 300 mg OXY/kg once daily for a total of 10 days (QD × 10), followed by a 3 day rest and an additional 6 days of dosing.
During 6 days of dosing with DCD the average recovery of the dosed DCD in urine was 82.3%, with a further 2.1% recovered in the faeces.
After 42 days of dosing with aleglitazar 0.03 mg/kg per day, mean body weight decreased significantly by about 5.9% from baseline (P = 0.043).
Steady-state concentrations are attained within 14 days of dosing.
Thus, even low doses will achieve a full effect after several days of dosing.
Unlike the adult OVX rabbit, this model requires only 10 days of dosing.
No adverse events were reported in any vaccine recipients within 3 days of dosing.
Visual assessment of individual trough concentrations (data not shown) suggested steady-state was achieved within 1 to 2 days of dosing.
Multiple doses of AZD9773 reduced circulating TNFα towards the limit of detection in most patients throughout the 5 days of dosing.
Electrocardiography, blood pressure, and heart rate were assessed during the pre-PK baseline, immediately prior to the initiation of aleglitazar, and after 42 days of dosing.
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