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At week 108, onabotulinumtoxinA treatment reduced headache day frequency by 10.7 days from baseline, P < 0.0001 (Fig. 4a), with mean (SD) headache days reduced to 11.3 (7.4) days per 28-day period (from 22.0 [4.8] days at baseline; P < 0.0001).
The primary outcome measurement was the cost-effectiveness ratio (C/E), expressed as cost per 1 day reduction of headache days from baseline to week 16.
Statistically significant reductions in headache day frequency were observed from the first assessment at week 24 (headache day frequency reduced by 7.4 days from baseline; P < 0.0001) and at all subsequent assessment points including week 60 (Fig. 4a).
Patient outcomes were assessed at 3 months and consisted of change in severity of symptomatology, level of daily functioning and activity limitation days from baseline.
The primary outcome measure used in the economic analysis was change in heroin-free days from baseline to the sixth month of treatment.
In the first 30 days from baseline, there was an interaction between treatment strategy and number of diseased vessels.
The primary endpoint was the change in monthly migraine days from baseline to the third treatment month.
(1) had change in mean monthly migraine days from baseline to weeks 5 8 as the primary endpoint.
In comparison to the control group, the intervention group increased their total and MVPA during school days from baseline to post-intervention (i.e. 4.49 min improvement).
Our analysis has shown that, in a real-life clinical setting, Botox can effectively reduce headache and migraine days, and increase crystal clear days from baseline.
All other studies had change in monthly migraine days from baseline to weeks 9 12 of the 12-week double-blind treatment phase as the primary endpoint.
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