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Healthy animals were trained daily for 3 days before baseline session, which was performed the week before the first fMRI session (pre-scan in Fig. 1).
The T0 questionnaire was completed 164.8 (s.d. 107.5) days before baseline screening, and the T1 questionnaire 2.5 (s.d. 6.5) days before baseline screening.
Drug exposure was defined as at least one dispensed prescription during the 91 days before baseline.
DMARDs other than MTX were to be discontinued at least 28 days before baseline.
We measured capillary glucose values before meals and 1.5 hours after meals during at least two days before baseline and at the end of follow-up.
Most adolescents had not received any mental health or behavioural treatment or other professional intervention in the 90 days before baseline assessment.
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Tc-99m DTPA GFR scintigrams were performed as a baseline 1 month (35.0 ± 5.2 days; range, 30 49 days) before surgery.
Bronchial biopsy specimens were taken 14 days before infection (baseline), at day 4 (acute infection), and at 6 weeks postinfection (convalescence).
Data used for the study was collected 10 days before launch (baseline, pre-flight), on landing day (1 2 h after landing), and 3 days after landing (post-flight), on shuttle missions lasting 8 16 days.
The HRQL used the questionnaire of the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) [ 14] completed by the patient from 0 to 7 days before chemotherapy (baseline) and at home 7 days after the chemotherapy (day 8) for both studies and on the first day of the second cycle of chemotherapy (day 15 29), for the second study.
Charts were included, if routinely conducted headache diaries were complete for 90 days before treatment (baseline) and over a treatment period of 180 days.
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