The task of designing and conducting such a trial is daunting.
However, the logistics of such studies are daunting, as a randomised trial comparing 1 month with 3 months of VTE prophylaxis, with significant power to reveal a 20% reduction in clinical VTE events (from 11 to 8.8%), would require 3000 patients per treatment arm.
In rare tumors, where large-scale clinical trials are daunting, this targeted genomic approach offers a new perspective and hope for improved treatments.
Now that he has officially taken up the role as the symbolic leader of the world's 80million Anglicans, Welby knows the trials he faces are daunting.
We should acknowledge that the choice of including all possible interventions that have ever been evaluated in randomised controlled trials on a topic can be daunting.
Zeenat (Gul Panag), on the other hand, faces the daunting task of saving the life of her husband, who is on trial for murder.
But the difficulties of conducting clinical trials or introducing experimental techniques in an emergency setting are daunting.
As daunting a task as it might seem, with Evans languishing at the slower end of trials qualifying in 51st, the three-time Olympian still speaks with infectious enthusiasm about competing again, free from expectation.
Yet mounting a trial against such a prominent defendant, who had billions to spend on his defense, was daunting.
