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Unpublished study enrolment dates were obtained using the study identification number from follow-up publications, ClinicalTrials.gov, fda.gov, Trial Trove, Prous Integrity, Adis Clinical Trial and Adis R&D Insight.
Thereafter, probabilities of dying q(x) and probabilities of surviving l(x) were determined i.e. q(x)=K (i ) D (i ) ; The reference dates were obtained using the model; (3) t (i ) =A(i +B (i )[ P(1)/P(2)]+C (i )[ P(2)/P (3 )] Where, A(i), B(i) and C i) are constant coefficients and were chosen from the North model life table.
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Dietary information over the year preceding diagnosis or the reference date was obtained using a FFQ.
Date was obtained using Feature Extraction software, version 10.7.3.1 (Agilent Technologies).
The most recent A1C value within 3 months of each participant's recruitment date was obtained using medical chart review at each of the recruitment sites.
With respect to the MODIS data treatments, the best results were obtained using date-of-acquisition interpolation of the 16-day composite VI time series and outlier point screening, for which five-year out-of-sample accuracies were consistently near or above 80% and Kappa values were above 0.60.
Chronologies of the deposit were obtained using two dating techniques: single stage accelerator mass spectrometer (SSAMS) 14C analysis of 23 charcoal samples and optically stimulated luminescence (OSL) dating of quartz from 6 sediment samples.
Hospitalization data since 1 January 1995 were obtained using probabilistic matching based on date of birth, gender, and postal code.
Chronologies for the Porto Maior site were obtained using a combination of electron spin resonance (ESR) dating of optically bleached quartz25,26 and post infrared-infrared stimulated (pIR-IR) luminescence dating applied to K-rich feldspar grains27,28.
Images were obtained using Pannoramic MIDI 3DHistech Ltd , Budapest, Hungary).
Results were obtained using SIRT1 specific ELISA.
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