All class II/III PI3K mutant mice reported to date were created by gene targeting approaches that remove the protein of interest but do not allow the discrimination between scaffold- and kinase-dependent functions of these enzymes (Vanhaesebroeck et al., 2005).
The complex and lyrically beautiful paintings, dating from 18,000 years ago, were created by the light of tallow cupped in limestone.
The researchers looked at tens of thousands of online dating profiles that were created by users with "extremely" or only "somewhat" positive or negative names.
Kievan Rus was converted to Christianity in 988, and in Kiev, its dominant political and cultural centre, mosaics dating from about 1045 were created by Byzantine craftsmen.
These 100 portraits dating from 1481 to 1989 were created by some of the most influential artists of their generations, such as William Blake, Constantin Brancusi, Jean-Antoine Houdon, Edouard Manet, Robert Nanteuil, Willem de Passe, and August Rodin.
According to Avery, Donatello's Ascension of Christ and the Giving of the Keys to St. Peter may have been intended to share the front of the sarcophagus, further strengthening the papal associations, which were created by dating Cossa's death using the ancient Roman Calends of January, which was uncommon on Florentine tombs, but was used in papal ones.
Stelae depicting falconry that were created by the Hittites date to the 13th century bce, and cave paintings from prehistoric sites may represent even earlier references to falconry.
The Light and Hope windows were created by the Franz Mayer and Company of Munich, Germany and date back to 1903.
Three replicate datasets were created by labeling and hybridizing the four tissue RNA samples on separate dates to introduce technical variation.
