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All dates were calculated as the weighted average of the relative dates from the relevant gene trees, with the contribution of a given gene tree to the node being weighted according to the bootstrap support of that node on the gene tree.
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Peak and trough dates are calculated as follows: begin{aligned} P_{t}&= 1~text{ if}~Delta y_{t}>0quad text{ and} quad Delta y_{t+1}<0 T_{t}&= 1 text{ if} Delta y_{t}<0quad text{ and} quad Delta y_{t+1}>0.
The average time from registration to start dates was calculated as the difference between the CTG registration and study start dates.
Pregnancy start date was calculated as being nine months before child birth-month, as child birthdate was provided to month of birth only and gestational age was not available.
The annual vegetation green-up date was calculated as the day of a study year when the corrected (anomalies caused by clouds, snow cover, orbital drifts and volcanic stratospheric aerosol) interpolated 1-day resolution NDVI crossed the threshold value.
The initiation pregnancy date was calculated as the date 40 weeks before the delivery event.
For healthy calves kept in group pens, the birth date was calculated as the mean between the birth dates of the youngest and oldest calf in the pen.
The C N ratio for each sampling date was calculated as the ratio of mean C to mean N, not the mean of the ratios for each sampled point, consistent with the watershed-scale budget.
Polypharmacy, the number of simultaneous repeat prescriptions at the reference date, was calculated as the number of drugs with at least two electronic records of prescription on different days within the last 12 months; different doses and switching between different brands of the same medication were not counted.
Missing dates were not allowed as dates were calculated and imputed for them.
Survival times were calculated as the date of primary tumour diagnosis to date of death, or date of censor, if alive.
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