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The average time from registration to start dates was calculated as the difference between the CTG registration and study start dates.
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Peak and trough dates are calculated as follows: begin{aligned} P_{t}&= 1~text{ if}~Delta y_{t}>0quad text{ and} quad Delta y_{t+1}<0 T_{t}&= 1 text{ if} Delta y_{t}<0quad text{ and} quad Delta y_{t+1}>0.
All dates were calculated as the weighted average of the relative dates from the relevant gene trees, with the contribution of a given gene tree to the node being weighted according to the bootstrap support of that node on the gene tree.
Pregnancy start date was calculated as being nine months before child birth-month, as child birthdate was provided to month of birth only and gestational age was not available.
The annual vegetation green-up date was calculated as the day of a study year when the corrected (anomalies caused by clouds, snow cover, orbital drifts and volcanic stratospheric aerosol) interpolated 1-day resolution NDVI crossed the threshold value.
The initiation pregnancy date was calculated as the date 40 weeks before the delivery event.
For healthy calves kept in group pens, the birth date was calculated as the mean between the birth dates of the youngest and oldest calf in the pen.
The C N ratio for each sampling date was calculated as the ratio of mean C to mean N, not the mean of the ratios for each sampled point, consistent with the watershed-scale budget.
Polypharmacy, the number of simultaneous repeat prescriptions at the reference date, was calculated as the number of drugs with at least two electronic records of prescription on different days within the last 12 months; different doses and switching between different brands of the same medication were not counted.
The estimated date of delivery was calculated as follows: if the woman was certain of the date of her last menstrual period (LMP), the estimated date of delivery was adjusted only if a scan at <16 weeks' gestation found a difference of seven or more days between the scan gestation and that calculated by the LMP or a scan at 19-21 weeks found a difference of 10 or more days.
The estimated date of conception (fertilization) was calculated as the date exactly 38 weeks prior to the due date.
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